US 12,403,313 B2
Methods and systems for estimating neural activation by stimulation using a stimulation system
Andrew James Haddock, Los Angeles, CA (US); Tianhe Zhang, Studio City, CA (US); and Mahsa Malekmohammadi, Sherman Oaks, CA (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Jun. 13, 2022, as Appl. No. 17/838,778.
Claims priority of provisional application 63/210,799, filed on Jun. 15, 2021.
Prior Publication US 2022/0395690 A1, Dec. 15, 2022
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61B 5/374 (2021.01)
CPC A61N 1/36128 (2013.01) [A61B 5/374 (2021.01); A61B 5/7246 (2013.01); A61B 5/748 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for estimating neural activation arising from deep brain stimulation by a stimulation system, the method comprising:
identifying a plurality of different anatomical structures of a brain stimulated by the deep brain stimulation;
for each of the different anatomical structures of the brain, providing at least one template signal for the anatomical structure of the brain;
obtaining a neural response signal resulting from the deep brain stimulation by the stimulation system;
decomposing the neural response signal in a time domain into a plurality of decomposed signals using the template signals to estimate neural activation of each of the different anatomical structures of the brain, wherein decomposing the neural response signal comprises decomposing the neural response signal using the template signals, wherein decomposing the neural response signal comprises determining weights for each of the template signals as portions of the neural response signal;
combining the template signals using the weights to generate a composite neural signal; and
using the estimated neural activations of each of the different anatomical structures of the brain to adjust stimulation settings of the stimulation system.