US 12,403,311 B2
System and method to induce epigenetic changes to the cells and tissue of the eye and orbit
Mark S. Humayun, Los Angeles, CA (US); Gianluca Lazzi, Los Angeles, CA (US); Bodour Salhia, Los Angeles, CA (US); Manjunath Machnoor, Los Angeles, CA (US); and Javad Paknahad, Los Angeles, CA (US)
Assigned to University of Southern California, Los Angeles, CA (US)
Appl. No. 17/766,600
Filed by UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA (US)
PCT Filed Oct. 28, 2020, PCT No. PCT/US2020/057680
§ 371(c)(1), (2) Date Apr. 5, 2022,
PCT Pub. No. WO2021/086924, PCT Pub. Date May 6, 2021.
Claims priority of provisional application 62/927,038, filed on Oct. 28, 2019.
Prior Publication US 2024/0100334 A1, Mar. 28, 2024
Int. Cl. A61N 1/36 (2006.01); A61N 1/04 (2006.01); A61N 1/40 (2006.01); C12Q 1/6874 (2018.01); C12Q 1/6883 (2018.01)
CPC A61N 1/36046 (2013.01) [A61N 1/0476 (2013.01); A61N 1/36014 (2013.01); A61N 1/40 (2013.01); C12Q 1/6874 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/154 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system comprising:
an external radiofrequency (RF) coil configured to transmit RF signals toward an eye of a user, the external RF coil configured to be spaced apart from the eye of the user when transmitting the RF signals; and
a wearable device including:
a curved material configured to be removably disposed on the eye and having an aperture located at a center of the curved material to allow for corneal oxygenation,
a plurality of internal RF coils located on or within the curved material and configured to receive the RF signals from the external RF coil, and
a plurality of stimulating electrodes including a positive electrode and a negative electrode electrically connected to the plurality of internal RF coils, the positive electrode positioned on the curved material and configured to electromagnetically stimulate a retina of the eye, causing changes to cells or tissue of the eye or causing changes to cells or tissue adjacent to the eye.