US 12,403,306 B2
Electric field shaping leads for treatment of cancer
Brian L. Schmidt, White Bear Lake, MN (US); Jacob M. Ludwig, Isanti, MN (US); Benjamin J. Haasl, Forest Lake, MN (US); and Michael J. Kane, St. Paul, MN (US)
Assigned to Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed by Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed on Oct. 22, 2018, as Appl. No. 16/167,079.
Claims priority of provisional application 62/575,687, filed on Oct. 23, 2017.
Prior Publication US 2019/0117970 A1, Apr. 25, 2019
Int. Cl. A61N 1/36 (2006.01); A61B 18/14 (2006.01); A61B 18/18 (2006.01); A61N 1/04 (2006.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01); A61N 5/02 (2006.01)
CPC A61N 1/36002 (2017.08) [A61B 18/14 (2013.01); A61B 18/18 (2013.01); A61N 1/0424 (2013.01); A61N 1/05 (2013.01); A61N 1/37247 (2013.01); A61N 5/02 (2013.01); A61N 1/36031 (2017.08); A61N 1/37229 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A lead for a cancer treatment system comprising:
a lead body having a proximal end and a distal end, the lead body having a lumen with a cuff disposed at the distal end of the lead body, the lead body comprising
one or more conductors disposed within the lead body and providing electrical communication; and
an insulating material disposed circumferentially about and along the lead body over the one or more conductors;
wherein the lead body comprises one or more first zones and one or more second zones, wherein the insulating material disposed over the one or more conductors in the first zones is thicker than the insulating material disposed over the one or more conductors in the second zones;
wherein the second zones comprise at least a portion of the one or more conductors and at least a portion of the insulating material to form an electric field generating electrode configured to generate one or more therapeutic electric fields at or near a site of a cancerous tumor;
wherein the portion of the insulating material disposed about the one or more conductors in the second zones is configured to manipulate a strength of the one or more therapeutic electric fields generated by the electric field generating electrodes within the second zones;
the second zones having a stronger electric field than the first zones; and
wherein the cuff is reinforced with a shape set material such that the cuff is in a first elongate rectangular configuration prior to implantation and a second curled cylindrical configuration when implanted around the site of the cancerous tumor;
wherein the cuff comprises two or more cuff electrodes disposed on the cuff, wherein each of the two or more cuff electrodes is activated independently; and
wherein the cuff expands in diameter by at least 50% without structural failure.