| CPC A61M 37/0084 (2013.01) [A61K 8/11 (2013.01); A61K 2800/43 (2013.01); A61K 2800/654 (2013.01); A61M 2202/0468 (2013.01); A61M 2205/051 (2013.01)] | 8 Claims |

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1. A sterile, single-use tattoo device comprising:
i) a hypodermic safety needle, and
ii) an ampoule made of plastic containing a semi-permanent, disappearing tattoo ink and a breakable membrane which allows ink to flow at the time of tattoo application;
wherein the semi-permanent, disappearing tattoo ink only remains visible to the naked eye for between 4 weeks and 18 months after it is tattooed on a patient's skin, is removed by the patient's immune system after it is tattooed on a patient's skin wherein the patient's immune system begins removing the semi-permanent, disappearing tattoo ink between 2 and 6 weeks after it is tattooed on a patient's skin, and wherein the semi-permanent, disappearing tattoo ink comprises:
a) particles, wherein the particles comprise:
i) a shell comprising bioabsorbable and biodegradable polymer; and
ii) a core comprising:
I) bioabsorbable and biodegradable polymers or a hydrogel matrix and a coloring agent having a molecular weight between 5 and 10×106 Daltons, wherein said coloring agent is intercalated, non-covalently, or covalently bound with the polymer or hydrogel matrix, and wherein the bioabsorbable and biodegradable polymer comprises a homopolymer, a copolymer, a diblock or triblock copolymer chosen from one or a combination of: polycaprolectone (PCL), poly L-lactic acid (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyethylene glycol-diacrylate (PEGDA), polyorthoester, aliphatic polyanhydride, or aromatic polyanhydride; or
II) a coloring agent having a molecular weight between about 5 and about 10×106 Daltons; wherein said coloring agent is encapsulated by the shell polymer wherein the shell bioabsorbable and biodegradable polymer comprises a first block or diblock polymer chosen from one or a combination of: polycaprolectone (PCL), poly L-lactic acid (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyethylene glycol-diacrylate (PEGDA), polyorthoester, aliphatic polyanhydride, poly(sebacic anhydride) (poly(SA)), or aromatic polyanhydride; and
b) a carrier solution.
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