| CPC A61M 5/162 (2013.01) [A61J 1/201 (2015.05); A61J 1/2051 (2015.05); A61M 5/1413 (2013.01); A61M 5/142 (2013.01); A61M 5/14248 (2013.01); A61M 5/1456 (2013.01); A61M 5/158 (2013.01); A61M 5/1626 (2013.01); A61M 39/18 (2013.01); A61J 1/1406 (2013.01); A61M 2005/14252 (2013.01); A61M 2005/1585 (2013.01); A61M 2005/2474 (2013.01); A61M 5/32 (2013.01); A61M 2005/341 (2013.01); A61M 2205/0216 (2013.01); A61M 2205/18 (2013.01); A61M 2205/581 (2013.01); A61M 2205/587 (2013.01)] | 27 Claims |

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1. A drug delivery device comprising:
a drug container having a longitudinal axis and a distal end with an opening covered by a pierceable seal;
a connection hub having a rigid wall, the rigid wall having a drug container facing surface and a radially inwardly facing surface, the radially inwardly facing surface being closer to the pierceable seal than the drug container facing surface, the radially inwardly facing surface at least partially defining an interior space, wherein the rigid wall and any component of the drug delivery device formed in one piece with the rigid wall is free from contact with a distalmost surface of the pierceable seal and any component of the drug delivery device contacting the distalmost surface of the pierceable seal; and
a piercing member having an unactuated position wherein a tip of the piercing member is exterior to the drug container, and a delivery position wherein the tip of the piercing member pierces through the pierceable seal into the drug container,
wherein the tip of the piercing member is configured to move through the interior space of the connection hub in moving from the unactuated position to the delivery position, and the piercing member is free from contact with the pierceable seal and any member disposed at least partially within the pierceable seal when the piercing member is in the unactuated positioned.
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