US 12,403,223 B2
Method for constructing hydrophilic antifouling coating on surface of medical implantable material
Zhimeng Niu, Taizhou (CN); and Qibo Xiao, Taizhou (CN)
Assigned to Taizhou DOBIOM Medical Devices Co., Ltd., Taizhou (CN)
Appl. No. 18/724,324
Filed by Taizhou DOBIOM Medical Devices Co., Ltd., Taizhou (CN)
PCT Filed Jun. 21, 2023, PCT No. PCT/CN2023/101763
§ 371(c)(1), (2) Date Jun. 26, 2024,
PCT Pub. No. WO2024/051272, PCT Pub. Date Mar. 14, 2024.
Claims priority of application No. 202211086394.8 (CN), filed on Sep. 6, 2022.
Prior Publication US 2024/0424172 A1, Dec. 26, 2024
Int. Cl. A61L 29/08 (2006.01); A61L 29/06 (2006.01); A61L 29/14 (2006.01)
CPC A61L 29/085 (2013.01) [A61L 29/06 (2013.01); A61L 29/14 (2013.01); A61L 2400/18 (2013.01); A61L 2420/02 (2013.01)] 6 Claims
 
1. A method for constructing a hydrophilic antifouling coating on a surface of a medical implantable material, comprising the following steps:
1) pretreating a surface of a medical implantable material to obtain a pretreated surface and/or a hydrophilic active site;
2) impregnating the medical implantable material that has been pretreated in step 1) in a precursor solution for a reaction so as to obtain a free radical reaction and/or polymerization site on the surface of the medical implantable material; and taking out the medical implantable material for later use;
3) performing a polymerization grafting reaction
after obtaining the free radical reaction and/or polymerization site on the surface of the medical implantable material in step 2), placing the medical implantable material in a reaction solution for the polymerization grafting reaction, wherein the reaction solution comprises a crosslinking agent, modified molecules and an initiator; and
4) after the reaction in step 3) is completed, performing washing and drying, thus finishing construction of a hydrophilic antifouling coating on the surface of the medical implantable material, wherein
in step 3), a mass percentage concentration of the modified molecules is 0.1-50%; a mass percentage concentration of the crosslinking agent is 0.001-50%; a reaction temperature is 10-100° C.; and a reaction time lasts for 1-10 h;
in step 3), the crosslinking agent is selected from an alternating-structure amino acid copolymer;
the structural formula of the alternating-structure amino acid copolymer is as follows:

OG Complex Work Unit Chemistry
abbreviated as [AB]n, wherein A is

OG Complex Work Unit Chemistry
B is

OG Complex Work Unit Chemistry
n is an integer; and n=2-10000;
R1 comprises the following structures: —CH2—CH2—CH2—NH2, —CH2—CH2—NH2, —CH2—CH2—CH2—CH2—NH2, and —CH2—CH2—NH—CNH—NH2; R2 comprises the following structures: —H, —CH2—CH—CH2, —CH2—CH2—CH—CH2, C6H5—CH2—, and —CH3—C6H4—O—CH3; and R3 comprises the following structures: —H, —CH3, —CH2—CH3, —CH2—CH2—CH3, —CH—(CH3)2, —CH2—COOH, —C(CH3)3, and —CH2—C6H5;
in step 3), the modified molecules are a hydrophilic substance or a mixture of the hydrophilic substance and a hydrophobic substance;
the hydrophilic substance is one or more of acrylates, zwitterionic substances, polyethylene glycol substances with different molecular weights, or polyvinylpyrrolidone; the acrylates comprise one or more of 2-hydroxyethyl methacrylate, 2-ethoxyethyl acrylate, and poly(ethylene glycol) methyl ether methacrylate; the zwitterionic substances comprise one or more of 2-methacryloyloxyethyl phosphorylcholine, carboxybetaine, and sulfobetaine; and
the hydrophobic substance comprises one or more of lauryl methacrylate, vinyltrimethylsilane, tert-butyl methacrylate, and cyclohexyl methacrylate.