	US 12,403,218 B2
	Biological valve material, preparation method, and cross-linking agent
Zhi-Hong Wang, Tianjin (CN); Jing Liu, Tianjin (CN); Xi-Gang Leng, Tianjin (CN); De-Ling Kong, Tianjin (CN); and Yi-Bo Qin, Tianjin (CN)
Assigned to CHINESE ACADEMY OF MEDICAL SCIENCES INSTITUTE OF BIOMEDICAL ENGINEERING, Tianjin (CN)
Appl. No. 16/966,466
Filed by CHINESE ACADEMY OF MEDICAL SCIENCES INSTITUTE OF BIOMEDICAL ENGINEERING, Tianjin (CN)
PCT Filed Jun. 24, 2019, PCT No. PCT/CN2019/092542 § 371(c)(1), (2) Date Jul. 31, 2020, PCT Pub. No. WO2019/206343, PCT Pub. Date Oct. 31, 2019.
Claims priority of application No. 201810373023.5 (CN), filed on Apr. 24, 2018.
Prior Publication US 2021/0030923 A1, Feb. 4, 2021
Int. Cl. A61L 27/36 (2006.01); A61L 27/50 (2006.01)

CPC A61L 27/3604 (2013.01) [A61L 27/3687 (2013.01); A61L 27/50 (2013.01); A61L 2430/20 (2013.01); A61L 2430/36 (2013.01); A61L 2430/40 (2013.01)]

17 Claims

1. A method for preparing a biological valve material, comprising:

decellularizing a raw swim bladder; and

cross-linking the decellularized swim bladder with a cross-linking agent to obtain a swim bladder derived biological valve material;

wherein the cross-linking agent comprises a cross-linking compound, the cross-linking compound comprises glutaraldehyde, and a mass percentage of glutaraldehyde in the cross-linking agent is in a range from 0.5% to 1%.