US 12,403,216 B2
Chemical modification of silk fibroin for fabrication of enzymatically crosslinked hydrogels with tunable gelation kinetics and bioactivity
Onur Hasturk, Medford, MA (US); Jaewon Choi, Cambridge, MA (US); and David L. Kaplan, Concord, MA (US)
Assigned to Trustees of Tufts College, Medford, MA (US)
Appl. No. 17/768,876
Filed by Trustees of Tufts College, Medford, MA (US)
PCT Filed Oct. 19, 2020, PCT No. PCT/US2020/056386
§ 371(c)(1), (2) Date Apr. 14, 2022,
PCT Pub. No. WO2021/077116, PCT Pub. Date Apr. 22, 2021.
Claims priority of provisional application 62/923,128, filed on Oct. 18, 2019.
Prior Publication US 2024/0082459 A1, Mar. 14, 2024
Int. Cl. A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/52 (2006.01)
CPC A61L 27/227 (2013.01) [A61L 27/3604 (2013.01); A61L 27/52 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A composition comprising tyramine-substituted silk fibroin, wherein a first phenol group of the tyramine-substituted silk fibroin is covalently crosslinked to a second phenol group of the tyramine-substituted silk fibroin.