US 12,403,200 B2
Methods and compositions for treating autoimmune diseases
Geoffrey O. Gillard, Harvard, MA (US); Jennifer Lynn Proctor, Medford, MA (US); Anthony Boitano, Newton, MA (US); and Michael Cooke, Boston, MA (US)
Assigned to Vor Biopharma Inc., Cambridge, MA (US)
Filed by Vor Biopharma Inc., Cambridge, MA (US)
Filed on Dec. 3, 2021, as Appl. No. 17/457,583.
Application 17/457,583 is a continuation of application No. PCT/US2020/036177, filed on Jun. 4, 2020.
Claims priority of provisional application 63/030,860, filed on May 27, 2020.
Claims priority of provisional application 62/968,870, filed on Jan. 31, 2020.
Claims priority of provisional application 62/944,988, filed on Dec. 6, 2019.
Claims priority of provisional application 62/933,279, filed on Nov. 8, 2019.
Claims priority of provisional application 62/882,310, filed on Aug. 2, 2019.
Claims priority of provisional application 62/863,141, filed on Jun. 18, 2019.
Claims priority of provisional application 62/857,232, filed on Jun. 4, 2019.
Prior Publication US 2022/0273811 A1, Sep. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/68 (2017.01); A61K 35/28 (2015.01); A61P 37/06 (2006.01)
CPC A61K 47/6831 (2017.08) [A61K 35/28 (2013.01); A61K 47/68035 (2023.08); A61K 47/6817 (2017.08); A61K 47/6819 (2017.08); A61K 47/6829 (2017.08); A61K 47/6849 (2017.08); A61P 37/06 (2018.01)] 24 Claims
 
1. A method of depleting a population of CD45+ cells in a human patient having an autoimmune disease, the method comprising administering to the patient having the autoimmune disease an effective amount of an antibody-drug conjugate (ADC) comprising an anti-CD45 antibody, or antigen binding portion thereof, conjugated to a cytotoxin via a linker,
wherein the cytotoxin is a pyrrolobenzodiazepine dimer, or an indolinobenzodiazepine pseudodimer, wherein:
i) the pyrrolobenzodiazepine dimer has a structure of formula:

OG Complex Work Unit Chemistry
wherein the wavy line indicates the attachment point of the linker; or
ii) the indolinobenzodiazepine pseudodimer has a structure of formula:

OG Complex Work Unit Chemistry
wherein the wavy line indicates the attachment point of the linker.