US 12,403,199 B2
Asymmetrically branched degradable polyethylene glycol derivative
Ken Hamura, Kawasaki (JP); Hiroki Yoshioka, Kawasaki (JP); Kazuki Osakama, Kawasaki (JP); and Nobuhiro Nishiyama, Tokyo (JP)
Assigned to NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
Appl. No. 17/763,516
Filed by NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
PCT Filed Sep. 25, 2020, PCT No. PCT/JP2020/036199
§ 371(c)(1), (2) Date Mar. 24, 2022,
PCT Pub. No. WO2021/060443, PCT Pub. Date Apr. 1, 2021.
Claims priority of application No. 2019-176251 (JP), filed on Sep. 26, 2019.
Prior Publication US 2022/0339290 A1, Oct. 27, 2022
Int. Cl. A61K 47/60 (2017.01); A61K 47/64 (2017.01)
CPC A61K 47/641 (2017.08) [A61K 47/60 (2017.08)] 12 Claims
 
1. A branched degradable polyethylene glycol derivative represented by the following formula (1), comprising, in a molecule, an oligopeptide that is degraded in the cells:

OG Complex Work Unit Chemistry
wherein k1 and k2 are each independently 1-12, j1 and j2 are each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and L1 and L2 are each independently a single bond or a divalent spacer.