	US 12,403,176 B2
	Hydrophobic silk fibroin compositions and methods of making the same
David L. Kaplan, Concord, MA (US); Krishna Kumar, Cambridge, MA (US); Vittorio Montanari, Medford, MA (US); Morgan Hawker, Clovis, CA (US); Julia Fountain, Medford, MA (US); and Junqi Wu, Medford, MA (US)
Assigned to Trustees of Tufts College, Medford, MA (US)
Appl. No. 17/907,404
Filed by Trustees of Tufts College, Medford, MA (US)
PCT Filed Mar. 25, 2021, PCT No. PCT/US2021/024253 § 371(c)(1), (2) Date Sep. 26, 2022, PCT Pub. No. WO2021/195445, PCT Pub. Date Sep. 30, 2021.
Claims priority of provisional application 62/994,618, filed on Mar. 25, 2020.
Prior Publication US 2023/0123989 A1, Apr. 20, 2023
Int. Cl. A61K 38/17 (2006.01); C08H 1/00 (2006.01); C08L 89/00 (2006.01)

CPC A61K 38/1767 (2013.01) [C08H 1/00 (2013.01); C08L 89/00 (2013.01)]

20 Claims

1. A composition comprising:

a modified silk comprising one or more haloalkyl substituents; and

one or more linking agents, wherein each of the one or more linking agents couples a respective one of the one or more haloalkyl substituents to a respective amino acid of the modified silk.