US 12,403,166 B2
Labisia pumila extract composition and its pharmaceutical formulation
Mustadza Muhamad, Selangor (MY); and Abdul Razak Mohd Isa, Selangor (MY)
Assigned to MEDIKA NATURA SDN. BHD., Selangor (MY)
Filed by MEDIKA NATURA SDN. BHD., Selangor (MY)
Filed on Oct. 7, 2022, as Appl. No. 17/961,940.
Claims priority of application No. PI2021006446 (MY), filed on Nov. 2, 2021.
Prior Publication US 2023/0134529 A1, May 4, 2023
Int. Cl. A61K 36/185 (2006.01)
CPC A61K 36/185 (2013.01) 5 Claims
 
1. A process for making a Labisia pumila extract consisting essentially of:
a) extracting dried Labisia pumila with aqueous ethanol at a ratio of between 1:5 to 1:20, respectively, in weight/volume at a temperature of 60° C.-100° C. for 2-6 hours in an extraction chamber to obtain a first extract;
b) filtering the first extract to obtain a first filtrate and a first plant residue;
c) re-extracting the first plant residue with aqueous ethanol at a temperature of 60° C.-100° C. for 2-6 hours in the extraction chamber to obtain a second extract;
d) filtering the second extract to obtain a second filtrate and a second plant residue;
e) concentrating the first extract and the second extract;
f) mixing the first concentrated extract and the second concentrated extract to form the Labisia pumila extract;
g) homogenizing the Labisia pumila extract with maldodextrins; and
h) spray-drying the Labisia pumila extract, wherein the dried Labisia pumila extract is prepared by drying leaves of the Labisia pumila plant at 40° C.-55° C. for 5 hours until a moisture content is 6%-8%; drying stems and roots of the Labisia pumila plant at 40° C.-55° C. for 6 hours until a moisture content is 6%-8%; and grinding the dried leaves, stems and roots of the Labisia pumila plant to a particle size of 2 mm-4 mm.