US 12,403,159 B2
Therapeutic metal complexes and ligands and methods of making and using the same
Joseph Beckman, Corvallis, OR (US); James Hurst, Beaverton, OR (US); John Sirois, Corvallis, OR (US); and Chris Beaudry, Corvallis, OR (US)
Assigned to Oregon State University, Corvallis, OR (US)
Filed by Oregon State University, Corvallis, OR (US)
Filed on Jan. 27, 2023, as Appl. No. 18/102,474.
Application 18/102,474 is a division of application No. 16/802,410, filed on Feb. 26, 2020, granted, now 11,596,651.
Application 16/802,410 is a continuation of application No. PCT/US2018/049163, filed on Aug. 31, 2018.
Claims priority of provisional application 62/553,714, filed on Sep. 1, 2017.
Prior Publication US 2023/0172977 A1, Jun. 8, 2023
Int. Cl. A61K 33/34 (2006.01); A61K 31/155 (2006.01); A61K 31/4545 (2006.01); A61K 45/06 (2006.01); C07F 1/08 (2006.01)
CPC A61K 33/34 (2013.01) [A61K 31/155 (2013.01); A61K 31/4545 (2013.01); A61K 45/06 (2013.01); C07F 1/08 (2013.01)] 15 Claims
 
1. A method of treating a motor neuron disease and/or a neurological disease, comprising administering (i) a compound having a structure according to Formula A or (ii) a dosage form containing the compound to a subject in need thereof,

OG Complex Work Unit Chemistry
wherein
M is copper or a radioactive isotope thereof;
R1 is aryl-(R5)n or heteroaryl-(R5)n;
R2 is selected from aryl, aryl-(R6)n, or CH3;
each of R5 and R6 independently is selected from alkoxy, amine, hydroxyl, nitro, halogen, C(CF3) 3, or CF3;
n is an integer ranging from 1 to 10; and
each of R3 and R4 independently is selected from —N(H)(CH2)n′CH3, —N(H)(CH2)n′CF3, —N [(CH2)n′CH3]2, or —N[(CH2)n′CF3]2, wherein each n′ independently is an integer selected from 0 to 9,
wherein the motor neuron disease and/or a neurological disease is amyotrophic lateral sclerosis (ALS), Parkinson's disease, Menkes disease, Lou Gehrig's disease, primary lateral sclerosis, Kennedy's syndrome, frontal temporal dementia associated with ALS, spinal muscular atrophy, or canine degenerative myelopathy.