US 12,403,139 B2
Methods and compositions for prevention and treatment of cardiac hypertrophy
Alexander Stokes, Honolulu, HI (US)
Assigned to University of Hawaii, Honolulu, HI (US)
Filed by University of Hawaii, Honolulu, HI (US)
Filed on Sep. 7, 2023, as Appl. No. 18/243,572.
Application 14/745,060 is a division of application No. 13/824,912, granted, now 9,084,786, issued on Jul. 21, 2015, previously published as PCT/US2011/058967, filed on Nov. 2, 2011.
Application 18/243,572 is a continuation of application No. 16/928,967, filed on Jul. 14, 2020, abandoned.
Application 16/928,967 is a continuation of application No. 16/181,204, filed on Nov. 5, 2018, abandoned.
Application 16/181,204 is a continuation of application No. 15/583,867, filed on May 1, 2017, granted, now 10,137,123, issued on Nov. 27, 2018.
Application 15/583,867 is a continuation of application No. 14/745,060, filed on Jun. 19, 2015, abandoned.
Claims priority of provisional application 61/409,781, filed on Nov. 3, 2010.
Prior Publication US 2024/0189303 A1, Jun. 13, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/496 (2006.01); A61K 31/00 (2006.01); A61K 31/497 (2006.01); A61P 9/04 (2006.01)
CPC A61K 31/496 (2013.01) [A61K 31/00 (2013.01); A61K 31/497 (2013.01); A61P 9/04 (2018.01)] 11 Claims
 
1. A method of reducing the plasma concentration of a marker of cardiac hypertrophy in a mammalian subject with cardiac hypertrophy comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TRPV1 inhibitor.