US 12,403,136 B2
Cannabinoid derivatives as pharmaceutically active compounds and methods of preparation thereof
Alan Silcock, Cambridge (GB); Benjamin Whalley, Cambridge (GB); Royston Gray, Cambridge (GB); Hannah Straker, Cambridge (GB); Karen Tse, Cambridge (GB); Alexander Cobb, London (GB); and Laura Bryant, Leigh-on-Sea (GB)
Assigned to JAZZ PHARMACEUTICALS RESEARCH UK LIMITED, Sittingbourne (GB)
Appl. No. 17/627,946
Filed by JAZZ PHARMACEUTICALS RESEARCH UK LIMITED, Sittingbourne (GB)
PCT Filed Jul. 17, 2020, PCT No. PCT/GB2020/051723
§ 371(c)(1), (2) Date Jan. 18, 2022,
PCT Pub. No. WO2021/014132, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. 1910389 (GB), filed on Jul. 19, 2019.
Prior Publication US 2022/0288055 A1, Sep. 15, 2022
Int. Cl. A61K 31/47 (2006.01); A61K 31/05 (2006.01); A61K 31/055 (2006.01); A61K 31/353 (2006.01); A61K 45/06 (2006.01); A61P 25/08 (2006.01); C07C 37/16 (2006.01); C07C 39/23 (2006.01); C07C 41/06 (2006.01); C07D 215/06 (2006.01); C07D 215/14 (2006.01); C07D 215/20 (2006.01); C07D 215/48 (2006.01); C07D 311/58 (2006.01); C07D 311/64 (2006.01)
CPC A61K 31/47 (2013.01) [A61K 31/05 (2013.01); A61K 31/055 (2013.01); A61K 31/353 (2013.01); A61K 45/06 (2013.01); A61P 25/08 (2018.01); C07C 37/16 (2013.01); C07C 39/23 (2013.01); C07C 41/06 (2013.01); C07D 215/06 (2013.01); C07D 215/14 (2013.01); C07D 215/20 (2013.01); C07D 215/48 (2013.01); C07D 311/58 (2013.01); C07D 311/64 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A compound of the general Formula I or a salt thereof

OG Complex Work Unit Chemistry
where X is either CH2; O; NBoc; NFMoc; NZ; NTs; NAc; NC (O)iPr; NBz or NH and Y is either H or OH.
 
2. A compound of general Formula II or a salt thereof

OG Complex Work Unit Chemistry
where X is either CH2; O; NBoc; NFMoc; NZ; NTs; NAc; NC (O) iPr; NBz or NH and Y is either H or OH.