US 12,403,127 B2
Specifically meso-substituted porphyrins and chlorins for photodynamic therapy
Hartwig Richard Arthur Golf, Berlin (DE); Arno Wiehe, Berlin (DE); Susanna Graefe, Jena (DE); Volker Albrecht, Nuthetal (DE); and Hans-Ulrich Reißig, Berlin (DE)
Assigned to Biolitec Unternehmensbeteiligungs II AG, Vienna (AT)
Filed by biolitec Unternehmensbeteiligungs II AG, Vienna (AT); and FREIE UNIVERSITÄT BERLIN, Berlin (DE)
Filed on Sep. 23, 2019, as Appl. No. 16/579,225.
Application 16/579,225 is a division of application No. 15/515,950, granted, now 10,456,375, previously published as PCT/IB2015/057501, filed on Sep. 30, 2015.
Claims priority of provisional application 62/057,353, filed on Sep. 30, 2014.
Prior Publication US 2020/0022955 A1, Jan. 23, 2020
Int. Cl. C07F 15/00 (2006.01); A61K 31/03 (2006.01); A61K 31/409 (2006.01); A61K 31/555 (2006.01); C07D 487/22 (2006.01); C07F 5/02 (2006.01)
CPC A61K 31/409 (2013.01) [A61K 31/03 (2013.01); C07D 487/22 (2013.01); C07F 5/02 (2013.01)] 6 Claims
 
1. A corrole compound based on the formulas 1 or 2

OG Complex Work Unit Chemistry
wherein X is NH, O or S;
M is 3H or a metal ion chosen from the group of Cu, Mn, Fe, or Ga;
R2 is a linear or branched alkyl chain with 2-4 carbon atoms and containing at least one hydroxyl moiety;
R2 is a substituent either in the meta- or poro-position of the phenyl ring with R2═—OH, —COOH, —COOY, —NHY, OY, —NH—Z—COOH, or —CO—Z—NH2;
wherein
Y is a polyethyleneglycol-residue with (CH2CH2O)nCH3 with n=1-30 or a carbohydrate moiety;
Z is peptides or oligopeptides.