US 12,403,108 B2
Non-enzymatic debriding agent and method of use thereof
Mitchell Sanders, Grafton, MA (US)
Assigned to Alira Health Boston LLC, Framingham, MA (US)
Filed by CMC Consulting Boston, Inc., Framingham, MA (US)
Filed on Jun. 21, 2017, as Appl. No. 15/628,908.
Application 15/628,908 is a continuation of application No. PCT/US2015/067521, filed on Dec. 22, 2015.
Claims priority of provisional application 62/095,220, filed on Dec. 22, 2014.
Prior Publication US 2020/0268695 A1, Aug. 27, 2020
Int. Cl. A61K 31/17 (2006.01); A61K 9/06 (2006.01); A61K 38/08 (2019.01); A61K 47/02 (2006.01); A61K 47/20 (2006.01); A61K 47/26 (2006.01); A61K 47/42 (2017.01)
CPC A61K 31/17 (2013.01) [A61K 9/06 (2013.01); A61K 38/08 (2013.01); A61K 47/02 (2013.01); A61K 47/20 (2013.01); A61K 47/26 (2013.01); A61K 47/42 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A non-enzymatic wound debriding agent for application to necrotic human tissue that includes eschar that develops slough, comprising:
100-500 mM urea;
a gentle detergent with a high critical micelle concentration (CMC) of greater than 19 mM, wherein the micelles have hydrophilic denaturing cores that include the urea;
sodium chloride;
a physiological buffer; and
water.