US 12,403,103 B2
Compositions and methods useful for treatment of respiratory illness
Kelly Lee Schmeichel, Cincinnati, OH (US); Jayant Eknath Khanolkar, Singapore (SG); Douglas William Gledhill, St. Peters, MO (US); Susan Elaine Criss, Maineville, OH (US); Niranjan Ramji, Mason, OH (US); and Elaine Rose Costeines, Maineville, OH (US)
Assigned to The Procter & Gamble Company, Cincinnati, OH (US)
Filed by The Procter & Gamble Company, Cincinnati, OH (US)
Filed on Aug. 2, 2021, as Appl. No. 17/391,642.
Application 17/391,642 is a continuation of application No. 16/109,835, filed on Aug. 23, 2018, granted, now 11,083,697.
Application 16/109,835 is a continuation of application No. 16/011,700, filed on Jun. 19, 2018, granted, now 11,077,074.
Application 16/011,700 is a continuation of application No. 11/408,299, filed on Apr. 21, 2006, granted, now 10,022,339, issued on Jul. 17, 2018.
Prior Publication US 2021/0353562 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/137 (2006.01); A61K 31/473 (2006.01); A61K 31/485 (2006.01); A61K 31/495 (2006.01); A61K 31/519 (2006.01); A61K 31/522 (2006.01); A61K 31/55 (2006.01); A61K 31/616 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/137 (2013.01) [A61K 31/473 (2013.01); A61K 31/485 (2013.01); A61K 31/495 (2013.01); A61K 31/519 (2013.01); A61K 31/522 (2013.01); A61K 31/55 (2013.01); A61K 31/616 (2013.01); A61K 45/06 (2013.01)] 51 Claims
 
1. A liquid composition comprising:
(a) phenylephrine hydrochloride;
(b) one or more additional actives selected from the group consisting of dextromethorphan hydrobromide, acetaminophen, guaifenesin, or combinations thereof;
(c) a flavorant;
(d) one or more sugar alcohols selected from the group consisting of glycerin and sorbitol or combinations thereof;
(e) one or more artificial sweeteners selected from the group consisting of sucralose, monoammonium glycyrrhizinate, or combinations thereof;
(f) one or more solvents selected from the group consisting of water and propylene glycol or combinations thereof;
(g) citric acid;
(h) sodium benzoate; and
(i) disodium ethylene diamine tetraacetic acid;
wherein the liquid composition has a pH of from about 2 to about 5;
wherein the liquid composition is a solution;
wherein the liquid composition comprises less than about 0.1%, by weight of the liquid composition, of aldehydes; and
wherein the liquid composition comprises a weight ratio of propylene glycol to glycerin of 1:1 to 4:1.