	US 12,403,094 B2
	Rheological solid oral composition
Matthew Lawrence Lynch, Mariemont, OH (US); Scott Kendyl Stanley, Mason, OH (US); Brandon Philip Illie, Felicity, OH (US); Taotao Zhu, West Chester, OH (US); Jamie Lynn Dria, Deerfield Township, OH (US); and Ashraf Traboulsi, West Chester, OH (US)
Assigned to The Procter & Gamble Company, Cincinnati, OH (US)
Filed by The Procter & Gamble Company, Cincinnati, OH (US)
Filed on Apr. 8, 2021, as Appl. No. 17/225,149.
Claims priority of provisional application 63/007,969, filed on Apr. 10, 2020.
Prior Publication US 2021/0322322 A1, Oct. 21, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61K 31/137 (2006.01); A61K 31/138 (2006.01); A61K 31/167 (2006.01); A61K 31/4402 (2006.01); A61K 47/12 (2006.01)

CPC A61K 9/2013 (2013.01) [A61K 9/282 (2013.01); A61K 31/137 (2013.01); A61K 31/138 (2013.01); A61K 31/167 (2013.01); A61K 31/4402 (2013.01); A61K 47/12 (2013.01)]

15 Claims

1. A rheological solid oral composition for delivering an oral active agent, comprising:

a crystallizing agent comprising a blend of salts of fatty acids containing from 13 to 16 carbon atoms; wherein the crystallizing agent blend has an Optimal Purity (Po) of greater than about 0.3 and a Single Purity (Ps) of greater than about 0.5;

an aqueous phase comprising water and a solvent; and

an oral active agent;

wherein the rheological solid composition comprises from about 80% to about 99.5% water and about 0.5% to about 15% solvent, by weight of the rheological solid oral composition;

wherein the rheological solid oral composition has a crystalline mesh comprising a rigid,

three-dimensional, interlocking crystalline skeleton framework of fiber-like crystalline particles formed from crystallizing agents, and the framework has voids or openings containing the aqueous phase and the oral active agent.