	US 12,403,091 B2
	Delivery system
Thomas Hnat, Santee, CA (US)
Assigned to SMARTECH TOPICAL, INC., Santee, CA (US)
Filed by SMARTECH TOPICAL, INC., Santee, CA (US)
Filed on Jun. 5, 2023, as Appl. No. 18/205,995.
Application 18/205,995 is a division of application No. 16/087,989, granted, now 11,666,531, previously published as PCT/US2017/025373, filed on Mar. 31, 2017.
Claims priority of provisional application 62/316,064, filed on Mar. 31, 2016.
Prior Publication US 2023/0310318 A1, Oct. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/06 (2006.01); A61K 9/00 (2006.01); A61K 31/167 (2006.01); A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 31/216 (2006.01); A61K 31/245 (2006.01); A61K 31/352 (2006.01); A61K 31/385 (2006.01); A61K 31/522 (2006.01); A61K 31/714 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/44 (2017.01)

CPC A61K 9/06 (2013.01) [A61K 9/0014 (2013.01); A61K 31/167 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/216 (2013.01); A61K 31/245 (2013.01); A61K 31/352 (2013.01); A61K 31/385 (2013.01); A61K 31/522 (2013.01); A61K 31/714 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/44 (2013.01)]

13 Claims

1. A method for the topical delivery of diclofenac to a subject in need thereof, comprising:

topically applying a non-aqueous transparent gel formulation to the subject, the non-aqueous transparent gel formulation comprising

(a) diclofenac;

(b) oleic acid;

(c) at least one organic solvent selected from the group consisting of dimethyl isosorbide, dimethyl formamide, ethanol, ethyl acetate, 1,2-propanediol, 1,3-propanediol, and glycerin;

(d) dimethylsulfoxide; and

(e) hydroxypropyl cellulose.