US 12,403,086 B2
Solid drug tablets for implantable drug delivery devices
Karen Danielle Daniel, Newton, MA (US); Burleigh M. Hutchins, III, Upton, MA (US); Cheryl Larrivee-Elkins, Framingham, MA (US); and Heejin Lee, Bedford, MA (US)
Assigned to TARIS Biomedical LLC, Lexington, MA (US)
Filed by TARIS Biomedical LLC, Lexington, MA (US)
Filed on Nov. 21, 2023, as Appl. No. 18/516,052.
Application 18/516,052 is a continuation of application No. 17/352,740, filed on Jun. 21, 2021, granted, now 11,844,856.
Application 17/352,740 is a continuation of application No. 16/932,229, filed on Jul. 17, 2020, granted, now 11,040,005, issued on Jun. 22, 2021.
Application 16/932,229 is a continuation of application No. 15/633,492, filed on Jun. 26, 2017, abandoned.
Application 15/633,492 is a continuation of application No. 13/729,974, filed on Dec. 28, 2012, granted, now 9,757,546, issued on Sep. 12, 2017.
Application 13/729,974 is a continuation of application No. 12/825,238, filed on Jun. 28, 2010, granted, now 8,343,516, issued on Jan. 1, 2013.
Claims priority of provisional application 61/241,382, filed on Sep. 10, 2009.
Claims priority of provisional application 61/220,865, filed on Jun. 26, 2009.
Prior Publication US 2024/0091136 A1, Mar. 21, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 31/165 (2006.01); A61K 31/167 (2006.01); A61M 31/00 (2006.01); B65B 1/16 (2006.01); A61K 31/16 (2006.01)
CPC A61K 9/0004 (2013.01) [A61K 9/0034 (2013.01); A61K 9/2027 (2013.01); A61K 9/2031 (2013.01); A61K 9/2072 (2013.01); A61K 9/2095 (2013.01); A61K 31/165 (2013.01); A61K 31/167 (2013.01); A61M 31/002 (2013.01); A61M 31/007 (2013.01); B65B 1/16 (2013.01); A61K 9/2004 (2013.01); A61K 31/16 (2013.01); A61M 2202/06 (2013.01)] 23 Claims
 
1. A method of manufacturing an assembly of tablets, comprising:
providing a plurality of tablets formed from a drug composition comprising a combination of a drug and one or more excipients, wherein the tablets are in the form of mini-tablets, wherein each mini-tablet is cylindrical with flat end faces, the length of the mini-tablet exceeding its diameter so that the mini-tablet has an aspect ratio of greater than 1:1;
arranging the plurality of tablets in a serial arrangement in which the flat end faces of adjacent tablets face one another; and
loading the serial arrangement into a drug delivery device which is configured for deployment within the body of a patient.