US 12,403,081 B2
Method of assessing and treating cellulite
Jeffrey Davidson, Downingtown, PA (US); Michael McLane, Lansdale, PA (US); and Genzhou Liu, North Wales, PA (US)
Assigned to Endo Operations Limited, Ballsbridge (IE)
Filed by Endo Operations Limited, Dublin (IE)
Filed on Oct. 9, 2023, as Appl. No. 18/482,998.
Application 18/482,998 is a division of application No. 17/461,481, filed on Aug. 30, 2021, granted, now 11,813,347.
Application 17/461,481 is a division of application No. 15/909,991, filed on Mar. 1, 2018, granted, now 11,123,280, issued on Sep. 21, 2021.
Claims priority of provisional application 62/607,188, filed on Dec. 18, 2017.
Claims priority of provisional application 62/485,705, filed on Apr. 14, 2017.
Claims priority of provisional application 62/465,622, filed on Mar. 1, 2017.
Prior Publication US 2024/0041744 A1, Feb. 8, 2024
Int. Cl. A61K 8/66 (2006.01); A61B 5/00 (2006.01); A61B 5/103 (2006.01); A61K 38/48 (2006.01); A61Q 19/06 (2006.01); A61B 5/107 (2006.01)
CPC A61K 8/66 (2013.01) [A61B 5/103 (2013.01); A61B 5/44 (2013.01); A61B 5/441 (2013.01); A61B 5/444 (2013.01); A61B 5/4848 (2013.01); A61K 38/4886 (2013.01); A61Q 19/06 (2013.01); C12Y 304/24003 (2013.01); A61B 5/1079 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for rating the severity of, and treating, cellulite in an affected area of a human subject, the method comprising:
rating the severity of the subject's cellulite using a validated photonumeric scale comprising 3 to 10 images showing an affected area of one or more example patients, the affected area in each of the 3 to 10 images of the example patients corresponding to the location of the affected area of the human subject, wherein each of the 3 to 10 images has a different severity rating comprising a numerical value, description, or both, the severity rating being based on a combination of two or more characteristics of cellulite selected from the group consisting of the number, depth, size, width, diameter, and distribution of dimples, wherein the photonumeric scale was validated using a test-retest reliability analysis; and
injecting into the affected area a pharmaceutical formulation comprising a mixture of collagenase I and collagenase II obtained or derived from Clostridium histolyticum to thereby treat the cellulite.