US 12,403,077 B2
Use of a new composition for preventing or slowing the appearance of signs of inflammation
Catherine Kern, Paris (FR); Christine Garcia, Castres (FR); Christian Gombert, Paris (FR); and Philippe Msika, Paris (FR)
Assigned to SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC, Paris (FR)
Appl. No. 17/046,538
Filed by SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC, Paris (FR)
PCT Filed Apr. 12, 2019, PCT No. PCT/FR2019/050870
§ 371(c)(1), (2) Date Oct. 9, 2020,
PCT Pub. No. WO2019/197789, PCT Pub. Date Oct. 17, 2019.
Claims priority of application No. 1853265 (FR), filed on Apr. 13, 2018.
Prior Publication US 2021/0154112 A1, May 27, 2021
Int. Cl. A61K 8/37 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 8/37 (2013.01) [A61Q 19/00 (2013.01); A61K 2800/75 (2013.01)] 2 Claims
 
1. A method of therapeutic treatment of inflammation of the human skin and/or the scalp, the method comprising:
I. providing a cosmetic composition (C1) comprising per 100% of mass:
a) from 60.0% by mass to 75.0% by mass of an organic solvent (SO1) selected from the group consisting of 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, and mixtures thereof;
b) from 0.1% by mass to 2.0% by mass of a composition (ES), wherein said composition (ES) comprises per 100% of mass:
greater than or equal to 200 mg/g of:
at least one compound of formula (Ia) corresponding to formula (I):

OG Complex Work Unit Chemistry
for which Q1 represents the maloyl radical of formula (IIIa) or of formula (IIIb):

OG Complex Work Unit Chemistry
and Q3 and Q4 and Q5, which are identical, each represent the caffeoyl radical of formula (II):

OG Complex Work Unit Chemistry
at least one compound of formula (Ib) corresponding to formula (I) for which Q1 represents the caffeoylmaloyl radical of formula (IVa) or of formula (IVb):

OG Complex Work Unit Chemistry
Q3 and Q5 each represent the caffeoyl radical of formula (II) and Q4 represents the hydroxyl radical, and
at least one compound of formula (Ic) selected from:
the compound of formula (Ic1) corresponding to formula (I) for which Q1 and Q5 each represent the caffeoyl radical of formula (II), Q3 represents the hydroxyl radical and Q4 represents the caffeoylmaloyl radical of formula (IVa) or of formula (IVb); and
the compound of formula (Ic2) corresponding to formula (I) for which Q1 and Q4 represent the caffeoyl radical of formula (II), Q3 represents the hydroxyl radical and Q5 represents the caffeoylmaloyl radical of formula (IVa) or of formula (IVb); and
c) from 20.0% by mass to 35.0% by mass of water;
wherein said composition (C1) is prepared from a process comprising the following successive stages:
a step a) of cultivating the plant Arctium lappa under soilless conditions, fed with a nutrient solution, so as to obtain a biomass (BM1);
a step b) of immersing the roots of said biomass (BM1) obtained in step a) above in a medium(S), such that the roots of said biomass (BM1)/medium (S1) ratio is between 0.5 kg/l and 1.5 kg/l, said medium (S1) comprising, per 100% of its own mass, from 20% to 35% by mass of water, the pH of said water having been adjusted to a value of between 1.5 and 3.5 by addition of a protic acid chosen from sulfuric acid, phosphoric acid and hydrochloric acid, and from 65% to 80% by mass of an organic solvent (SO1) selected from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol or a mixture of these diols;
a step c) of separating the roots of the biomass at the end of the treatment defined in step b), to isolate a liquid phase (L1) and a biomass (BM2);
a step d) of immersing said biomass (BM2) resulting from step c) in said medium (S1); in a biomass (BM2)/medium (S1) ratio of between 0.1 kg/l and 1.5 kg/l;
a step e) of separating of said biomass (BM2) at the end of the treatment defined in step d), to isolate a liquid phase (L2);
a step f) of filtering said liquid phase (L2) obtained in step e), to remove residual solids and isolate a liquid phase (L3); and
a step g) of mixing said liquid phases (L1) and (L3), then, if necessary, adding water and/or said organic solvent (SO1), so as to obtain the expected composition (C1); and
II. applying an effective amount of composition C1 to the skin.