| CPC A61B 18/1492 (2013.01) [A61B 2018/00351 (2013.01); A61B 2018/00357 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00648 (2013.01); A61B 2018/00702 (2013.01); A61B 2018/00708 (2013.01); A61B 2018/00761 (2013.01); A61B 2018/00791 (2013.01); A61B 2018/00797 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00839 (2013.01); A61B 18/1206 (2013.01); A61B 2090/065 (2016.02); A61N 1/327 (2013.01)] | 14 Claims | 

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               1. A method of treating target tissue of a patient's heart with pulsed field energy, the heart having a cardiac cycle, the method comprising: 
            positioning a medical device adjacent to the target tissue, the medical device being in communication with a control unit having a pulsed field energy delivery generator; 
                determining timing of the cardiac cycle and an optimal time within the cardiac cycle for pulsed field energy delivery; 
                evaluating proximity between a plurality of energy delivery electrodes and the target tissue to determine whether the plurality of energy delivery electrode are is in close proximity with the target tissue; 
                evaluating distance between specific energy delivery electrodes of the plurality of energy delivery electrodes; and 
                delivering pulsed field energy to the target tissue during the optimal time within the cardiac cycle for pulsed field energy delivery from the at least one energy delivery electrode that is determined to be in close proximity with the target tissue and satisfy a distance threshold between specific energy delivery electrodes. 
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