US 12,402,937 B2
Initiating IRE generation with a ramp
Assaf Govari, Haifa (IL); and Andres Claudio Altmann, Haifa (IL)
Assigned to Biosense Webster (Israel) Ltd., Yokneam (IL)
Filed by BIOSENSE WEBSTER (ISRAEL) LTD., Yokneam (IL)
Filed on Feb. 16, 2022, as Appl. No. 17/672,823.
Claims priority of provisional application 63/159,412, filed on Mar. 10, 2021.
Prior Publication US 2022/0287764 A1, Sep. 15, 2022
Int. Cl. A61B 18/00 (2006.01); A61B 18/14 (2006.01); A61B 18/16 (2006.01); A61B 18/12 (2006.01)
CPC A61B 18/1485 (2013.01) [A61B 18/16 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00821 (2013.01); A61B 2018/00839 (2013.01); A61B 2018/126 (2013.01); A61B 2018/167 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for ablating tissue in a patient, comprising:
providing a probe, comprising an electrode, configured to be inserted into a lumen of the patient, so that the electrode is in proximity to the tissue to be ablated;
injecting an immobilizing signal into the patient, via the electrode, that is configured to immobilize the patient; and
when the patient is immobilized, injecting an ablation signal via the electrode into the patient, the ablation signal being configured to ablate the tissue by irreversible electroporation,
wherein the ablation signal comprises at least one train of first pulses, each of the first pulses in the at least one train having a first pulse absolute amplitude, and
wherein the immobilizing signal comprises a plurality of trains of second pulses, each of the second pulses in the plurality of trains having a second pulse absolute amplitude below a threshold value to ablate the tissue by irreversible electroporation and wherein the absolute amplitude of the plurality of trains of second pulses increases monotonically in time.