US 12,402,870 B2
Bioadhesive materials and minimally invasive methods for adhering tissues with bioadhesive materials
Xuanhe Zhao, Allston, MA (US); Hyunwoo Yuk, Cambridge, MA (US); Sarah J Wu, Cambridge, MA (US); and Christoph Nabzdyk, Rochester, MN (US)
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US); and MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, Rochester, MN (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Oct. 8, 2021, as Appl. No. 17/497,497.
Claims priority of provisional application 63/091,105, filed on Oct. 13, 2020.
Prior Publication US 2022/0110619 A1, Apr. 14, 2022
Int. Cl. A61B 17/00 (2006.01); A61B 17/072 (2006.01); A61L 24/06 (2006.01); A61M 25/10 (2013.01)
CPC A61B 17/00491 (2013.01) [A61B 17/07292 (2013.01); A61L 24/06 (2013.01); A61B 2017/00526 (2013.01); A61B 2017/00938 (2013.01); A61L 2400/06 (2013.01); A61M 25/10 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A folded bioadhesive sleeve for introduction to a target tissue surface using minimally invasive techniques comprising:
a multilayer bioadhesive material comprising a dry bioadhesive layer having a bottom surface and a top surface, and a non-adhesive layer disposed on the top surface of the dry bioadhesive layer;
wherein the multilayer bioadhesive material is in the configuration of a multilayer bioadhesive patch, tape, film, strip, or sheet,
wherein the multilayer bioadhesive materials is folded into a hollow sleeve shape comprising an inner passageway and an outer surface, wherein the inner passageway is defined by an inner surface formed of portions of the non-adhesive layer,
wherein the outer surface is an adhesive surface;
wherein, in a folded configuration, the multilayer bioadhesive material is configured to be in an origami-based design; and
wherein the bottom surface of the dry bioadhesive layer is micro-textured,
wherein the micro-textured surface is configured to comprise a plurality of surface imbedded microparticles, embossed micropatterns, molded micro-textures, patterned micro-textures, surface etched textures, spun micro- or nano-fibers, or combinations thereof.