| CPC A61B 5/686 (2013.01) | 20 Claims |

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1. A system, comprising:
electrodes configured to be implanted in a body;
pulse generator (PG) circuitry to deliver a stimulus to one or more of the electrodes, the stimulus having a signal characteristic of interest (COI);
sensing circuitry configured to define a sensing channel between one or more of the electrodes to sense signals indicative of a physiologic activity of interest, the sensing circuitry further configured to collect a calibration signal over the sensing channel;
wherein the sensing circuitry and PG circuitry are housed within an implantable medical device (IMD);
one or more processors; and
a memory coupled to the one or more processors, the memory configured to store program instructions that are executable by the one or more processors to:
determine a signal COI of the calibration signal;
compare the signal COI of the stimulus to the signal COI of the calibration signal; and
adjust a parameter of the sensing circuitry or PG circuitry based on the comparison.
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