US 12,402,828 B2
Methods for the detection of brain injury
James Christopher Edgar, Philadelphia, PA (US)
Assigned to THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US)
Appl. No. 17/438,483
Filed by THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US)
PCT Filed Mar. 13, 2020, PCT No. PCT/US2020/022581
§ 371(c)(1), (2) Date Sep. 13, 2021,
PCT Pub. No. WO2020/186148, PCT Pub. Date Sep. 17, 2020.
Claims priority of provisional application 62/817,737, filed on Mar. 13, 2019.
Prior Publication US 2022/0151534 A1, May 19, 2022
Int. Cl. A61B 5/374 (2021.01); A61B 5/00 (2006.01); A61B 5/245 (2021.01)
CPC A61B 5/374 (2021.01) [A61B 5/245 (2021.01); A61B 5/4848 (2013.01); A61B 2503/06 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for detecting and treating an acute or sub-acute mild traumatic brain injury in a subject comprising
a) measuring an alpha activity in the brain of said subject, wherein an increase in the alpha activity in the brain of said subject compared to control subjects without a brain injury or to a baseline of said subject is indicative of said patient subject having the acute or sub-acute mild traumatic brain injury, wherein said alpha activity is measured when the subject is in a resting state; and
b) administering a pain or headache medication to the subject with the increase in the alpha activity in the brain compared to the control subjects without the brain injury or to the baseline of said subject.