US 12,402,826 B2
Closed-loop vagus nerve stimulation
Jacob A. Levine, West Hempstead, NY (US); and Michael A. Faltys, Valencia, CA (US)
Assigned to SetPoint Medical Corporation, Valencia, CA (US)
Filed by SetPoint Medical Corporation, Valencia, CA (US)
Filed on Mar. 12, 2024, as Appl. No. 18/603,165.
Application 17/337,292 is a division of application No. 14/782,715, granted, now 11,051,744, issued on Jul. 6, 2021, previously published as PCT/US2014/033690, filed on Apr. 10, 2014.
Application 18/603,165 is a continuation of application No. 17/337,292, filed on Jun. 2, 2021, granted, now 11,969,253.
Claims priority of provisional application 61/810,690, filed on Apr. 10, 2013.
Prior Publication US 2024/0215900 A1, Jul. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/349 (2021.01); A61B 5/00 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01); A61N 1/37 (2006.01); A61N 1/372 (2006.01); A61N 1/375 (2006.01); A61N 1/378 (2006.01)
CPC A61B 5/349 (2021.01) [A61B 5/4047 (2013.01); A61B 5/4836 (2013.01); A61B 5/6877 (2013.01); A61N 1/0551 (2013.01); A61N 1/36053 (2013.01); A61N 1/36139 (2013.01); A61N 1/3702 (2013.01); A61N 1/37205 (2013.01); A61N 1/3756 (2013.01); A61N 1/3787 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of closed-loop modulation of an inflammatory reflex, the method comprising:
sensing electrical activity on a vagus nerve from a microstimulator implanted around the vagus nerve;
determining a pattern of activity characteristic of tachyphylaxis based on neural feedback on patient accommodation to stimulus, wherein determining the pattern of activity characteristic of tachyphylaxis comprises accessing a neural signature database comprising neural signatures at various levels of inflammation before and after vagus nerve stimulation and comparing a sensed neural signature to the neural signature database to determine patient accommodation to stimulus;
adjusting one or more stimulation parameters to prevent tachyphylaxis based on the pattern of activity characteristic of tachyphylaxis;
determining a treatment dosage effective for treating inflammation using the adjusted one or more stimulation parameters; and
delivering the treatment dosage to a patient using the adjusted one or more stimulation parameters.