US 12,402,801 B2
Pathologies diagnosis using a spectral electrical impedance device
Fabián José Bonetto, Rio Negro (AR); Mario Joaquín Saravia, Ciudad Autónoma de Buenos Aires (AR); and Mariela Inés Bellotti, Rio Negro (AR)
Assigned to IMPEL IP, LLC, Wilmington, DE (US)
Appl. No. 18/857,631
Filed by IMPEL IP, LLC, Wilmington, DE (US)
PCT Filed Apr. 21, 2023, PCT No. PCT/US2023/019327
§ 371(c)(1), (2) Date Oct. 17, 2024,
PCT Pub. No. WO2023/205373, PCT Pub. Date Oct. 26, 2023.
Claims priority of provisional application 63/333,799, filed on Apr. 22, 2022.
Prior Publication US 2025/0120607 A1, Apr. 17, 2025
Int. Cl. A61B 5/00 (2006.01); A61B 3/10 (2006.01); A61B 5/0538 (2021.01)
CPC A61B 5/0538 (2013.01) [A61B 3/101 (2013.01); A61B 5/6821 (2013.01); A61B 5/725 (2013.01); A61B 5/7253 (2013.01); A61B 2560/0468 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A device to measure a raw electrical digitized signal used in an algorithm using reference and sensor voltage measurements in order to calculate, as main parameters, resistance and capacitance as a function of frequency for measuring the raw electrical digitized signal of a patient's ocular surface and intraocular structures, at a minimum measurement time, comprising:
a sensor including an electrode connected to the device consisting of at least a microelectrode, a material acting as an insulator, and a material acting as a ground, that is adapted to contact the patient's ocular surface and intraocular structures,
wherein the device measures an impedance over a range of alternating current (AC) frequencies of the electrode when a current flows uniformly and radially through a tear film space above the patient's ocular surface, and
wherein the device comprises a continuously variable frequency current source of logarithmic sweep, a voltage digitizer, a digital low pass filter system and sensitive phase detection algorithm using a Hilbert transform to obtain a quadrature signal from a reference signal.