US 12,072,403 B2
System and method of perceptive quantitative mapping of physical properties
Yi Wang, New York, NY (US); Zhe Liu, New York, NY (US); Jinwei Zhang, New York, NY (US); Qihao Zhang, New York, NY (US); Junghun Cho, New York, NY (US); and Pascal Spincemaille, New York, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Filed by Cornell University, Ithaca, NY (US)
Filed on Sep. 25, 2023, as Appl. No. 18/474,048.
Application 18/474,048 is a continuation of application No. 17/614,277, granted, now 11,782,112, previously published as PCT/IB2020/055079, filed on May 28, 2020.
Claims priority of provisional application 62/853,290, filed on May 28, 2019.
Prior Publication US 2024/0012080 A1, Jan. 11, 2024
Int. Cl. G01R 33/56 (2006.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/565 (2006.01); G06T 7/00 (2017.01)
CPC G01R 33/5608 (2013.01) [A61B 5/0042 (2013.01); A61B 5/055 (2013.01); A61B 5/7221 (2013.01); A61B 5/7267 (2013.01); G01R 33/56536 (2013.01); G06T 7/0012 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for generating one or more images of an object, the system comprising:
a processor;
a display communicatively coupled to the processor;
an input interface communicatively coupled to the processor;
a non-transitory computer storage medium encoded with a computer program, the program comprising instructions that when executed by the processor cause the processor to perform operations comprising:
acquiring time-resolved image data capturing tracer passage in tissue of the object;
solving an inverse problem of fitting the image data to a transport equation or a concentration—transport relationship that is expressed as a relationship between a concentration of the tracer at a given location and transport parameters at that location, wherein the relationship comprises a temporal change of a local concentration at the given location and a local divergence of mass flux, wherein the mass flux comprises the concentration multiplied by a velocity, and wherein solving the inverse problem comprises:
estimating a transport distribution of the tissue of the object using prior knowledge about a tissue transport parameter distribution characterized by an artificial neural network or using tissue morphological information having a sparsity characterized velocity distribution; and
generating one or more images of the object based on the estimated transport distribution of the object; and
presenting, on a display device, the one or more images of the object generated based on the solving of the inverse problem.