US 12,072,402 B2
Multiphoton magnetic resonance imaging
Chunlei Liu, Orinda, CA (US); and Victor Han, Berkeley, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed on May 24, 2022, as Appl. No. 17/664,799.
Application 17/664,799 is a continuation of application No. PCT/US2020/063410, filed on Dec. 4, 2020.
Claims priority of provisional application 62/943,354, filed on Dec. 4, 2019.
Prior Publication US 2022/0334203 A1, Oct. 20, 2022
Int. Cl. G01R 33/389 (2006.01); A61B 5/055 (2006.01); G01R 33/3815 (2006.01); G01R 33/385 (2006.01)
CPC G01R 33/389 (2013.01) [A61B 5/055 (2013.01); G01R 33/3815 (2013.01); G01R 33/3852 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A multiphoton magnetic resonance imaging (MRI) system, the system comprising:
(a) a magnetic resonance imager having a main magnet, gradient coils and at least one RF coil (B1,xy) in a transverse plane;
(b) at least one additional RF Coil (B1,z) configured to apply one or more fields along a z-axis, parallel to a main magnetic field B0 of said magnetic resonance imager; and
(c) a controller operably coupled to said coils configured to generate multiple magnetic field frequencies that excite multiphoton resonances in a target to generate a signal for MRI imaging while none of the frequencies is near the Larmor frequency and to read generated MRI signals from the target.