US 12,072,400 B2
Strongly-interacting magnetic particle imaging
Steven Conolly, Walnut Creek, CA (US); Carlos Rinaldi, Gainesville, FL (US); Bo Zheng, Seattle, WA (US); Prashant Chandrasekharan, Berkeley, CA (US); Daniel Hensley, Emeryville, CA (US); Shehaab Savliwala, Gainesville, FL (US); Zhi Wei Tay, Singapore (SG); and Rohan Deepak Dhavalikar, Hillsboro, OR (US)
Assigned to The Regents of the University of California, Oakland, CA (US); and University of Florida Research Foundation, Incorporated, Gainesville, FL (US)
Appl. No. 17/629,301
Filed by The Regents of the University of California, Oakland, CA (US); and University of Florida Research Foundation, Incorporated, Gainesville, FL (US)
PCT Filed Jul. 23, 2020, PCT No. PCT/US2020/043307
§ 371(c)(1), (2) Date Jan. 21, 2022,
PCT Pub. No. WO2021/016473, PCT Pub. Date Jan. 28, 2021.
Claims priority of provisional application 62/877,601, filed on Jul. 23, 2019.
Prior Publication US 2022/0260655 A1, Aug. 18, 2022
Int. Cl. G01R 33/12 (2006.01); A61B 5/0515 (2021.01)
CPC G01R 33/1276 (2013.01) [A61B 5/0515 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A strongly-interacting magnetic particle imaging system, comprising:
a magnetic field generating system comprising at least one magnet, the magnetic field generating system providing:
a gradient magnetic field within an observation region of the magnetic particle imaging system such that the gradient magnetic field will have a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein; and
a drive field plus a slow shift field that dynamically shifts the FFR across a field of view (FOV) or partial FOV (pFOV) within the observation region, where a trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the strongly-interacting magnetic particles in the FOV or pFOV are saturated to a full coercivity field substantially immediately prior to traversing to an opposite-polarity of coercivity;
a detection system arranged proximate the observation region, the detection system being configured to detect an induction signal from the strongly-interacting magnetic particles to provide a detection signal; and
a signal processor in communication with the detection system, wherein the processor is configured to:
receive the detection signal from the detection system;
process the detection signal to remove a coercivity shift due to the coercivity of the strongly-interacting magnetic particles; and
convert the processed detection signal into an image of the strongly-interacting magnetic particles.