	US 12,072,344 B2
	Automated fluid handling system
Johan Blomberg, Uppsala (SE); and Mats Lundkvist, Uppsala (SE)
Assigned to GE Healthcare Bio-Science AB, Uppsala (SE)
Filed by Cytiva Sweden AB, Uppsala (SE)
Filed on Apr. 5, 2023, as Appl. No. 18/131,043.
Application 18/131,043 is a continuation of application No. 16/788,836, filed on Feb. 12, 2020, granted, now 11,650,219.
Application 16/788,836 is a continuation of application No. 15/624,547, filed on Jun. 15, 2017, granted, now 10,598,678, issued on Mar. 24, 2020.
Application 15/624,547 is a continuation of application No. 15/205,956, filed on Jul. 8, 2016, granted, now 9,709,591, issued on Jul. 18, 2017.
Application 15/205,956 is a continuation of application No. 15/165,876, filed on May 26, 2016, granted, now 9,709,589, issued on Jul. 18, 2017.
Application 15/165,876 is a continuation of application No. 14/463,039, filed on Aug. 19, 2014, granted, now 9,404,902, issued on Aug. 2, 2016.
Application 14/463,039 is a continuation of application No. 13/376,929, granted, now 8,821,718, issued on Sep. 2, 2014, previously published as PCT/SE2010/050624, filed on Jun. 4, 2010.
Claims priority of application No. 0950431-7 (SE), filed on Jun. 9, 2009.
Prior Publication US 2023/0243861 A1, Aug. 3, 2023
Int. Cl. G01N 35/10 (2006.01); B01D 15/10 (2006.01); B01D 29/60 (2006.01); G01N 30/24 (2006.01); G01N 30/38 (2006.01); G01N 30/88 (2006.01); B01D 15/08 (2006.01); B01D 17/12 (2006.01); G01N 30/02 (2006.01); G01N 35/00 (2006.01)

CPC G01N 35/1097 (2013.01) [B01D 15/10 (2013.01); B01D 29/60 (2013.01); G01N 30/24 (2013.01); G01N 30/38 (2013.01); G01N 30/88 (2013.01); B01D 15/08 (2013.01); B01D 17/12 (2013.01); B01D 2201/54 (2013.01); G01N 2030/027 (2013.01); G01N 2030/8804 (2013.01); G01N 2030/8881 (2013.01); G01N 2035/00326 (2013.01); Y10T 137/6416 (2015.04); Y10T 137/6525 (2015.04); Y10T 137/6851 (2015.04); Y10T 137/85986 (2015.04); Y10T 137/87885 (2015.04)]

9 Claims

1. A column valve for an automated liquid chromatography system, the column valve comprising:

i. two or more pairs of column connection ports each for connecting a chromatography column therebetween;

ii. an inlet port;

iii. an outlet port;

wherein the valve is configured for selective connection of a column connected to a pair of column connector ports by connecting the inlet port to one of the ports in the pair of column connector ports and the outlet port to the other port of the pair of column connector ports, and wherein the valve further comprises integrated pressure sensors integrated into the inlet and outlet ports of the valve, whereby the automated liquid chromatography system can measure the actual pressure over the connected column, and a liquid flow direction can be set from the top of the column to the bottom of the column, and from the bottom of the column to the top of the column.