US 12,072,329 B2
Spatial separation of particles in a particle containing solution for biomedical sensing and detection
Hansong Zeng, Acton, MA (US); and Gert Blankenstein, Cambridge, MA (US)
Assigned to Instrumentation Laboratory Company, Bedford, MA (US)
Filed by Instrumentation Laboratory Company, Bedford, MA (US)
Filed on Oct. 24, 2017, as Appl. No. 15/791,734.
Application 15/791,734 is a division of application No. 14/992,284, filed on Jan. 11, 2016, granted, now 11,959,907.
Claims priority of provisional application 62/102,308, filed on Jan. 12, 2015.
Prior Publication US 2018/0052147 A1, Feb. 22, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/49 (2006.01); B01L 3/00 (2006.01); G01N 1/40 (2006.01); G01N 33/50 (2006.01)
CPC G01N 33/49 (2013.01) [B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); G01N 1/4077 (2013.01); G01N 33/491 (2013.01); B01L 2200/0647 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0439 (2013.01); G01N 33/5002 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A system comprising:
a channel to receive whole blood comprised of blood cells and plasma, the whole blood forming a fluid column in the channel;
a plurality of acoustic transducers including a first acoustic transducer to apply acoustic force to the fluid column in the channel to form a fluid layer in the channel, the fluid layer comprising the plasma, the fluid layer being substantially free of the blood cells, and the fluid layer being adjacent to a particle layer comprising the blood cells;
an optical detector that is aligned with the fluid layer to perform detection on the fluid layer to detect an analyte through measurement of the fluid layer;
wherein the first acoustic transducer is configured to apply the acoustic force at a first region of the channel;
wherein the plurality of acoustic transducers includes a second acoustic transducer configured to apply acoustic force at a different region of the channel than the first region; and
wherein the optical detector comprises a spectrometer.