US 12,072,310 B2
Dielectric sensing to characterize properties of a sample under test
Pedram Mohseni, Highland Heights, OH (US); Lalitha Nayak, Solon, OH (US); Michael Suster, Cleveland, OH (US); and Sina Pourang, Cleveland Heights, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US); and UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Aug. 21, 2023, as Appl. No. 18/236,059.
Application 18/236,059 is a continuation of application No. 17/852,828, filed on Jun. 29, 2022, granted, now 11,774,388.
Application 17/852,828 is a continuation in part of application No. 16/837,704, filed on Apr. 1, 2020, granted, now 11,408,844, issued on Aug. 9, 2022.
Claims priority of provisional application 63/275,019, filed on Nov. 3, 2021.
Claims priority of provisional application 62/828,286, filed on Apr. 2, 2019.
Prior Publication US 2024/0110884 A1, Apr. 4, 2024
Int. Cl. G01N 27/22 (2006.01); B01L 3/00 (2006.01)
CPC G01N 27/221 (2013.01) [B01L 3/502715 (2013.01); B01L 2200/10 (2013.01); B01L 2300/023 (2013.01); B01L 2300/0663 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An apparatus, comprising:
a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber adapted to receive a volume of a fluid sample, a bioactive agent adapted to interact with the fluid sample, as a sample under test (SUT), within the microfluidic chamber;
a transmitter to provide an input radio frequency (RF) signal to an RF input of the dielectric microsensor;
a receiver to receive an output RF signal from an RF output of the dielectric microsensor; and
a computing device configured to compute dielectric permittivity values for the SUT based on the output RF signal over a time interval, the dielectric permittivity values being representative of the bioactive agent interacting with the sample over the time interval, the computing device further configured to provide a readout representative of one or more properties of the fluid sample based on the dielectric permittivity values.