US 12,071,611 B2
Rare cell capture system and application thereof
Hubing Shi, Chengdu (CN); Yanchu Li, Chengdu (CN); Qi Xu, Chengdu (CN); Xiangju Kong, Chengdu (CN); Xueyan Wang, Chengdu (CN); and Hewen Han, Chengdu (CN)
Assigned to Chengdu Precisome Biotechnology Co., Ltd., (CN); and Qiang Xu, (CN)
Appl. No. 17/255,381
Filed by Chengdu Precisome Biotechnology Co., Ltd., Chengdu (CN); and Qiang Xu, Hangzhou (CN)
PCT Filed Jul. 3, 2019, PCT No. PCT/CN2019/094629
§ 371(c)(1), (2) Date Dec. 22, 2020,
PCT Pub. No. WO2020/001662, PCT Pub. Date Jan. 2, 2020.
Claims priority of application No. 201810666625.X (CN), filed on Jun. 26, 2018.
Prior Publication US 2021/0269763 A1, Sep. 2, 2021
Int. Cl. B01L 3/00 (2006.01); A61M 1/36 (2006.01); B01F 23/00 (2022.01); B01F 23/41 (2022.01); B01F 101/23 (2022.01); B23Q 17/24 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12N 5/09 (2010.01); C12Q 1/18 (2006.01); G01N 21/3577 (2014.01); G01N 21/359 (2014.01); G01N 21/39 (2006.01); G01N 21/45 (2006.01); G01N 21/64 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC C12M 47/04 (2013.01) [A61M 1/3679 (2013.01); C12N 5/0693 (2013.01); A61M 2205/0244 (2013.01); C12N 2509/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A fluid component capture system, comprising a fluid tube device, a circulating power apparatus device, and a component capture device, wherein the circulating power apparatus device and the component capture device are connected in series to a fluid circulating system via the fluid tube device to form an extracorporeal fluid circulating pathway, the fluid tube device further comprises a bypass tube connected in parallel with the component capture device, the bypass tube is provided with a flow-limiting valve configured to adjust the flow rate; the component capture device comprises a microfluidic chip or a chipset, the flow-limiting valve which is arranged in series or in parallel with the microfluidic chip, the microfluidic chip comprises a substrate layer and a cover sheet layer sequentially arranged from bottom to top, a component capture chamber is arranged between the substrate layer and the cover sheet layer, a fluid inlet and a fluid outlet communicating with the component capture chamber are arranged on the cover sheet layer, the component capture chamber is divided into a buffer zone and a lane portion, the lane portion is divided into two or more lanes arranged in parallel by setting a bypass flow block, and a pin-fin row array is arranged in the lane in a flow direction, the pin-fin rows are arranged in parallel in the lane at specific intervals of 0.5 to 1 diameter of pin-fin row.