| CPC C09B 11/24 (2013.01) [C12Q 1/6876 (2013.01)] | 15 Claims |
|
1. A compound represented by Formula I:
 or a stereoisomer, tautomer, or salt thereof, wherein:
R1 is C1-C6 alkyl or L1-X;
R2 is halogen or SO2NH2,
R3 is H or halogen;
R4, R7, R8, and R11 when taken alone are independently H, halogen, or optionally substituted C1-C6 alkyl,
R5, R6, R9, and R10 when taken alone are independently H or optionally substituted C1-C6 alkyl;
R4 and R5 when taken together are an optionally substituted C2-C3 alkylene chain connecting the atoms to which R4 and R5 are attached;
R6 and R7 when taken together are an optionally substituted C2-C3 alkylene chain connecting the atoms to which R6 and R7 are attached;
R8 and R9 when taken together are an optionally substituted C2-C3 alkylene chain connecting the atoms to which R8 and R9 are attached;
R10 and R11 when taken together are an optionally substituted C2-C3 alkylene chain connecting the atoms to which R10 and R11 are attached;
R5 and R6, when taken together with the nitrogen atom to which R5 and R6 are attached, form a 5-membered or a 6-membered unsaturated ring;
R9 and R10, when taken together with the nitrogen atom to which R9 and R10 are attached, form a 5-membered or a 6-membered unsaturated ring;
L1 is an optionally substituted C2-C10 alkylene or optionally substituted C2-C20 heteroalkylene;
X is —O—P(OCH2CH2CN)NR12R13 or
 wherein
L3 and L4 are independently an optionally substituted C2-C10 alkylene or optionally substituted C2-C30 heteroalkylene;
Q is a hydroxyl protecting group;
Z is CH, N, NHC(O)N, or OC(O)N; and
R12 and R13 are independently optionally substituted C1-C6 alkyl.
|