US 12,071,475 B2
Antibodies that bind transforming growth factor beta (TGF beta) and methods of use thereof for treatment
Daniel H. Bedinger, Pleasant Hill, CA (US); Shireen S. Khan, Castro Valley, CA (US); Amer M. Mirza, San Francisco, CA (US); Ajay J. Narasimha, San Francisco, CA (US); and Toshihiko Takeuchi, Oakland, CA (US)
Assigned to XOMA TECHNOLOGY LTD., Emeryville, CA (US)
Filed by XOMA TECHNOLOGY LTD., Emeryville, CA (US)
Filed on Jul. 15, 2021, as Appl. No. 17/376,933.
Application 17/376,933 is a division of application No. 16/435,022, filed on Jun. 7, 2019, granted, now 11,098,111.
Application 16/435,022 is a continuation of application No. 15/622,955, filed on Jun. 14, 2017, granted, now 10,358,486.
Application 15/622,955 is a continuation of application No. 14/808,666, filed on Jul. 24, 2015, granted, now 9,714,285.
Application 14/808,666 is a continuation of application No. 14/038,436, filed on Sep. 26, 2013, granted, now 9,145,458.
Application 14/038,436 is a continuation of application No. 13/486,983, filed on Jun. 1, 2012, granted, now 8,569,462.
Claims priority of provisional application 61/493,230, filed on Jun. 3, 2011.
Prior Publication US 2021/0355204 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/22 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/22 (2013.01) [A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/30 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/64 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 19 Claims
 
1. An antibody that binds transforming growth factor beta (TGFβ)1, TGFβ2 and TGFβ3 comprising:
(a) a heavy chain CDR1 amino acid sequence set forth in SEQ ID NO: 19;
(b) a heavy chain CDR2 amino acid sequence set forth in SEQ ID NO: 20;
(c) a heavy chain CDR3 amino acid sequence set forth in SEQ ID NO: 21;
(d) a light chain CDR1 amino acid sequence set forth in SEQ ID NO: 22;
(e) a light chain CDR2 amino acid sequence set forth in SEQ ID NO: 23; and
(f) a light chain CDR3 amino acid sequence set forth in SEQ ID NO: 24,
wherein the antibody is an IgG2 antibody.