	US 12,071,471 B2
	Immunoglobulins directed to bacterial, viral and endogenous polypetides
Sudhir Paul, Missouri City, TX (US); Stephanie Planque, Houston, TX (US); Yasuhiro Nishiyama, Houston, TX (US); Eric L. Brown, Houston, TX (US); Keri C. Smith, Houston, TX (US); and Hiroaki Taguchi, Houston, TX (US)
Assigned to COVALENT BIOSCIENCE INCORPORATED, Tuxedo Park, NY (US)
Filed by COVALENT BIOSCIENCE INCORPORATED, Tuxedo Park, NY (US)
Filed on May 14, 2018, as Appl. No. 15/978,801.
Application 15/978,801 is a continuation of application No. 12/589,440, filed on Oct. 23, 2009, granted, now 9,969,797.
Application 12/589,440 is a continuation of application No. PCT/US2008/005221, filed on Apr. 23, 2008.
Claims priority of provisional application 60/913,335, filed on Apr. 23, 2007.
Prior Publication US 2019/0144528 A1, May 16, 2019
Int. Cl. C07K 16/18 (2006.01); C07K 16/10 (2006.01); C07K 16/12 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/18 (2013.01) [C07K 16/1063 (2013.01); C07K 16/109 (2013.01); C07K 16/1271 (2013.01); G01N 33/6854 (2013.01); A61K 2039/505 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/622 (2013.01)]

17 Claims

1. A method for identifying an immunoglobulin (Ig) variable (V) domain of a light chain subunit (VL) or heavy chain subunit (VH) of an immunoglobulin having a specific, defined antigenic-directed activity comprising:

performing a screening of a library containing a plurality of IgV domains for the desired antigenic-directed activity, wherein said plurality of IgV domains comprise IgV domains which are a single IgV domain,

wherein the antigen of said IgV is an amyloid protein or a superantigen other than gp120; said IgV comprises a nucleophilic site; said IgV catalyzes the hydrolysis of said amyloid protein or superantigen; and said IgV is obtained from an organism without prior immunization with said antigen.