US 12,071,470 B2
Human immunodeficiency virus neutralizing antibodies and methods of use thereof
Johannes Scheid, New York, NY (US); Michel Nussenzweig, New York, NY (US); Pamela J. Bjorkman, Altadena, CA (US); and Ron Diskin, Rehovot (IL)
Assigned to The Rockefeller University, New York, NY (US); and California Institute of Technology, Pasadena, CA (US)
Filed by The Rockefeller University, New York, NY (US); and California Institute of Technology, Pasadena, CA (US)
Filed on Feb. 22, 2023, as Appl. No. 18/172,836.
Application 15/719,738 is a division of application No. 14/118,496, granted, now 9,783,594, issued on Oct. 10, 2017, previously published as PCT/US2012/038400, filed on May 17, 2012.
Application 18/172,836 is a continuation of application No. 17/248,143, filed on Jan. 11, 2021, granted, now 11,634,478.
Application 17/248,143 is a continuation of application No. 15/719,738, filed on Sep. 29, 2017, granted, now 10,889,633, issued on Jan. 12, 2021.
Claims priority of provisional application 61/486,960, filed on May 17, 2011.
Prior Publication US 2023/0365661 A1, Nov. 16, 2023
Int. Cl. G01N 33/569 (2006.01); C07K 16/10 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/1045 (2013.01) [C07K 16/1063 (2013.01); G01N 33/56983 (2013.01); A61K 2039/505 (2013.01); C07K 2317/10 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 22 Claims
 
1. An isolated bispecific anti-HIV antibody or antigen binding portion thereof, comprising a first antigen-binding arm and a second antigen-binding arm,
wherein the first antigen-binding arm and the second antigen-binding arm bind specifically to different epitopes or molecules,
wherein the first antigen-binding arm comprises
the CDR1, CDR2, and CDR3 regions of the sequence of SEQ ID NO: 892, and the CDR1, CDR2 and CDR3 regions of the sequence of SEQ ID NO: 906, wherein the CDR1, CDR2, and CDR3 regions of the sequence of SEQ ID NO: 892 are DYFIH (SEQ ID NO: 1139), WINPKTGQPNNPROFQG (SEQ ID NO: 1140), and QRSDYWDFDV (SEQ ID NO: 1141), respectively; and the CDR1, CDR2, and CDR3 regions of the sequence of SEQ ID NO: 906 are QANGYLN (SEQ ID NO: 1142), DGSKLER (SEQ ID NO:1143), and QVYEF (SEQ ID NO: 1144), respectively.