US 12,071,439 B2
Process and intermediates for preparing a JAK inhibitor
Jiacheng Zhou, Newark, DE (US); Shili Chen, Newark, DE (US); Zhongjiang Jia, Kennett Square, PA (US); Pingli Liu, Wilmington, DE (US); David Meloni, Bear, DE (US); Yongchun Pan, Wilmington, DE (US); Naijing Su, Hockessin, DE (US); and Michael Xia, Wilmington, DE (US)
Assigned to Incyte Corporation, Wilmington, DE (US)
Filed by Incyte Corporation, Wilmington, DE (US)
Filed on Jul. 11, 2022, as Appl. No. 17/861,597.
Claims priority of provisional application 63/220,752, filed on Jul. 12, 2021.
Prior Publication US 2023/0059389 A1, Feb. 23, 2023
Int. Cl. C07D 487/04 (2006.01); C07D 205/04 (2006.01)
CPC C07D 487/04 (2013.01) [C07D 205/04 (2013.01)] 31 Claims
 
1. A process of preparing baricitinib, or a salt thereof, comprising:
reacting a compound of formula 3:

OG Complex Work Unit Chemistry
or a salt thereof, with a reagent which is selected from: (i) a salt of formula 2a, and (ii) a compound of formula 2b:

OG Complex Work Unit Chemistry
wherein X− is a counter anion.