US 12,071,433 B2
HMOX1 inducers
Margaret Biddle, Cambridge, MA (US); Arthur Kluge, Lincoln, MA (US); Sanjita Sasmal, Bangalore (IN); Bharat Lagu, Acton, MA (US); Xinyuan Wu, Chestnut Hill, MA (US); Takashi Ogiyama, Ibaraki (JP); and Eric Bell, Somerville, MA (US)
Assigned to Astellas Engineered Small Molecules US, Incorporated, Cambridge, MA (US)
Filed by Astellas Engineered Small Molecules US, Incorporated, Cambridge, MA (US)
Filed on Oct. 6, 2023, as Appl. No. 18/377,606.
Application 18/377,606 is a continuation of application No. 17/602,584, previously published as PCT/US2020/027240, filed on Apr. 8, 2020.
Claims priority of provisional application 62/932,629, filed on Nov. 8, 2019.
Claims priority of provisional application 62/833,031, filed on Apr. 12, 2019.
Prior Publication US 2024/0051952 A1, Feb. 15, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 413/14 (2006.01); A61P 9/08 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 513/04 (2006.01)
CPC C07D 413/14 (2013.01) [A61P 9/08 (2018.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 513/04 (2013.01)] 11 Claims
 
1. A compound represented by structural formula (III-B):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
R1 is —C(═O)NH((C1-C4)hydroxyalkoxy(C1-C4)alkyl), —C(═O)NH(hydroxy(C1-C4)alkyl), —C(═O)NH(methoxy(C1-C4)alkyl), or —C(═O)NH(hydroxy(C1-C4)alkoxy); and
R2 is OCH2CH2OCH3.