CPC C07D 231/56 (2013.01) [C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 409/04 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01)] | 31 Claims |
1. A compound, or a pharmaceutically acceptable salt thereof, having a structure according to Formula I:
wherein:
n is 1 or 2;
m is 2, 3, 4, 5, 6, 7, or 8, provided that when n is 1, m is 2, 3, 4, 5, or 6;
each R1 is independently selected from the group consisting of halo, —OH, and —O—(C1-C3 alkyl);
R2 is selected from the group consisting of —C1-C6 alkyl, —CN, and —S(O)2—(C1-C3 alkyl), wherein the —C1-C6 alkyl and —S(O)2—(C1-C3 alkyl) are substituted with 0-3 halo;
R3 is selected from the group consisting of —C1-C2 alkyl substituted with 1-3 R4, —C3-C6 alkyl, —C3-C8 cycloalkyl, -3- to 7-membered heterocycloalkyl having 1-3 heteroatom or heteroatom groups selected from N, O, S, S(═O), and S(═O)2, —Y—(C3-C6 cycloalkyl), —Y—O—(C3-C6 cycloalkyl), —Y-(3- to 6-membered heterocycloalkyl) having 1-3 heteroatom or heteroatom groups selected from N, O, S, S(═O), and S(═O)2, —X-(phenyl), and —Y-(5- to 6-membered heteroaryl) having 1-3 heteroatoms selected from N, O, and S, wherein the —C3-C6 alkyl, —C3-C8 cycloalkyl, -3- to 7-membered heterocycloalkyl, —Y—(C3-C6 cycloalkyl), —Y—O—(C3-C6 cycloalkyl), —Y-(3- to 6-membered heterocycloalkyl), —X-(phenyl), and —Y-(5- to 6-membered heteroaryl), are independently substituted with 0-3 R4;
each R4 is independently selected from halo, —C1-C6 alkyl, —CN, —C1-C6 haloalkyl, —OH, —O—(C1-C6 alkyl), —Y—O—(C1-C6 alkyl), —S—(C1-C6 alkyl), —S(O)—(C1-C6 alkyl), and —S(O)2—(C1-C6 alkyl), wherein the —O—(C1-C6 alkyl), —Y—O—(C1-C6 alkyl), —S—(C1-C6 alkyl), —S(O)—(C1-C6 alkyl), and —S(O)2—(C1-C6 alkyl) are independently substituted with 0-3 halo;
X is —C2-C3 alkylene-; and
Y is —C1-C3 alkylene-.
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