US 12,070,629 B2
Core stabilized microcapsules, method of their preparation and uses thereof
Ofer Toledano, Kfar Saba (IL); Haim Bar-Simantov, Netanya (IL); Hanan Sertchook, Gedera (IL); Sharon Fireman-Shoresh, Tel-Aviv (IL); and Dorit Marco, Rehovot (IL)
Assigned to Sol-Gel Technologies Ltd., Ness Ziona (IL)
Filed by Sol-Gel Technologies Ltd., Ness Ziona (IL)
Filed on Jun. 7, 2021, as Appl. No. 17/340,334.
Application 15/834,805 is a division of application No. 13/500,937, granted, now 10,512,796, previously published as PCT/IL2010/001092, filed on Dec. 30, 2010.
Application 17/340,334 is a continuation of application No. 15/924,331, filed on Mar. 19, 2018, granted, now 11,071,878.
Application 15/924,331 is a continuation in part of application No. 15/834,805, filed on Dec. 7, 2017, abandoned.
Claims priority of provisional application 61/291,594, filed on Dec. 31, 2009.
Prior Publication US 2021/0290985 A1, Sep. 23, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61Q 19/00 (2006.01); A61K 8/11 (2006.01); A61K 8/25 (2006.01); A61K 8/26 (2006.01); A61K 8/38 (2006.01); A61K 8/67 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/10 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); B01J 13/14 (2006.01); B01J 13/18 (2006.01); F28D 20/02 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01)
CPC A61Q 19/00 (2013.01) [A61K 8/11 (2013.01); A61K 8/25 (2013.01); A61K 8/26 (2013.01); A61K 8/38 (2013.01); A61K 8/671 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 9/10 (2013.01); A61K 9/501 (2013.01); A61K 9/5115 (2013.01); A61K 9/5192 (2013.01); B01J 13/14 (2013.01); B01J 13/18 (2013.01); F28D 20/023 (2013.01); A61K 9/5026 (2013.01); A61K 47/32 (2013.01); A61K 47/38 (2013.01); A61K 2800/412 (2013.01)] 8 Claims
 
1. A microcapsule comprising a core encapsulated by a metal oxide shell, wherein said core comprises at least one active agent, and at least one phase changing material; wherein the thickness of said metal oxide shell is in the range of 0.05-1 micron;
wherein said metal oxide shell is made from (a) metal oxide nanoparticles, and (b) a hydrolyzed and polymerized sol gel precursor; wherein said at least one active agent is in a solid form, and is a dermatological agent; wherein said at least one phase changing material is not liquid at room temperature; wherein said core has a viscosity of from about 300 cP to about 1,000,000 cP.