US 12,070,618 B2
Systems and methods for photoactivating a photosensitizer applied to an eye
Marc D. Friedman, Needham, MA (US); Mikhail Smirnov, North Andover, MA (US); and Pavel Kamaev, Lexington, MA (US)
Assigned to AVEDRO, INC., Waltham, MA (US)
Filed by Avedro, Inc., Waltham, MA (US)
Filed on Nov. 8, 2021, as Appl. No. 17/521,276.
Application 17/521,276 is a continuation of application No. 16/384,099, filed on Apr. 15, 2019, granted, now 11,167,149.
Application 16/384,099 is a continuation of application No. 15/137,748, filed on Apr. 25, 2016, granted, now 10,258,809, issued on Apr. 16, 2019.
Claims priority of provisional application 62/279,951, filed on Jan. 18, 2016.
Claims priority of provisional application 62/152,568, filed on Apr. 24, 2015.
Claims priority of provisional application 62/152,533, filed on Apr. 24, 2015.
Prior Publication US 2022/0054858 A1, Feb. 24, 2022
Int. Cl. A61N 5/06 (2006.01); A61F 9/007 (2006.01); A61F 9/02 (2006.01)
CPC A61N 5/0624 (2013.01) [A61F 9/0079 (2013.01); A61F 9/029 (2013.01); A61N 5/062 (2013.01); A61M 2202/0208 (2013.01); A61M 2205/3368 (2013.01); A61M 2205/36 (2013.01); A61M 2205/52 (2013.01); A61M 2210/0612 (2013.01); A61N 2005/0626 (2013.01); A61N 2005/0648 (2013.01); A61N 2005/0661 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for antimicrobial treatment, comprising:
identifying an eye infected by a microbe;
applying a photosensitizer to the eye;
applying a photoactivation device to the eye, the photoactivation device including:
a body defining a chamber shaped to be positioned over the eye;
one or more photoactivating light sources coupled to the body; and
an inlet configured to couple the body to an oxygen source;
modifying oxygen conditions in the chamber by delivering oxygen from the oxygen source via the inlet; and
operating the one or more photoactivating light sources to deliver photoactivating light to the eye according to illumination parameters that determine a dose of the photoactivating light that activates the photosensitizer applied to the eye,
wherein activation of the photosensitizer provides an antimicrobial effect in the eye depending on the oxygen conditions including at least an oxygen concentration.