US 12,070,607 B2
Method and apparatus for clinical effects-based targeting of neurostimulation
Tianhe Zhang, Studio City, CA (US); Michael A. Moffitt, Solon, OH (US); Richard Mustakos, Simi Valley, CA (US); and Stephen Carcieri, Los Angeles, CA (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Oct. 27, 2022, as Appl. No. 17/975,468.
Application 17/975,468 is a continuation of application No. 17/137,907, filed on Dec. 30, 2020, granted, now 11,517,755.
Application 17/137,907 is a continuation of application No. 15/902,163, filed on Feb. 22, 2018, granted, now 10,905,887.
Claims priority of provisional application 62/476,952, filed on Mar. 27, 2017.
Prior Publication US 2023/0045684 A1, Feb. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/37 (2006.01); A61B 5/00 (2006.01); A61N 1/02 (2006.01); A61N 1/36 (2006.01); A61N 1/372 (2006.01); G16H 20/40 (2018.01); A61B 5/24 (2021.01); A61N 1/05 (2006.01)
CPC A61N 1/37241 (2013.01) [A61B 5/4836 (2013.01); A61B 5/6868 (2013.01); A61N 1/025 (2013.01); A61N 1/3605 (2013.01); A61N 1/36125 (2013.01); A61N 1/36128 (2013.01); A61N 1/36132 (2013.01); A61N 1/36135 (2013.01); A61N 1/36139 (2013.01); A61N 1/36146 (2013.01); A61N 1/36185 (2013.01); G16H 20/40 (2018.01); A61B 5/24 (2021.01); A61B 5/7435 (2013.01); A61N 1/0534 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for delivering neurostimulation from a stimulation device to tissue of a patient through a plurality of electrodes, the system comprising:
a programming control circuit configured to generate information for programming the stimulation device to control delivery of the neurostimulation according to a stimulation configuration defining one or more stimulation waveforms and one or more electrode configurations; and
a stimulation control circuit configured to determine the stimulation configuration, the stimulation control circuit including:
volume definition circuitry configured to determine one or more test volumes, to determine one or more clinical effects each resulting from a test volume of the one or more test volumes being activated by the neurostimulation, and to determine a target volume using the one or more test volumes and the one or more clinical effects; and
stimulation configuration circuitry configured to automatically generate the specified stimulation configuration for activating a stimulation volume substantially matching the target volume by executing an inverse modeling algorithm using a stimulation field model (SFM) relating the stimulation configuration to the stimulation volume and at least one of a library including data mapping volumes of activation to stimulation configurations or an analytical derivation of the stimulation configuration that generates the stimulation volume,
wherein the one or more test volumes, the target volume, and the stimulation volume each represent a portion of the tissue.