US 12,070,604 B2
Optimizing neuromodulation stimulation parameters using blood parameter sensing
Brian Pepin, South San Francisco, CA (US); and Shiv Sabesan, South San Francisco, CA (US)
Assigned to GALVANI BIOELECTRONICS LIMITED, Stevenage (GB)
Filed by Galvani Bioelectronics Limited, Brentford (GB)
Filed on Oct. 8, 2021, as Appl. No. 17/450,308.
Application 17/450,308 is a continuation of application No. 16/485,673, granted, now 11,167,143, previously published as PCT/US2018/017831, filed on Feb. 12, 2018.
Claims priority of provisional application 62/458,757, filed on Feb. 14, 2017.
Prior Publication US 2022/0023635 A1, Jan. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61N 1/375 (2006.01)
CPC A61N 1/36139 (2013.01) [A61N 1/0534 (2013.01); A61N 1/36007 (2013.01); A61N 1/36031 (2017.08); A61N 1/36067 (2013.01); A61N 1/36135 (2013.01); A61N 1/3614 (2017.08); A61N 1/36171 (2013.01); A61N 1/36175 (2013.01); A61N 1/36062 (2017.08); A61N 1/36064 (2013.01); A61N 1/36071 (2013.01); A61N 1/36085 (2013.01); A61N 1/36096 (2013.01); A61N 1/3752 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A system comprising:
a neurostimulator configured to delivery stimulation for a nerve or artery/nerve plexus based on a first set of stimulation parameters;
one or more sensors configured to monitor a response to the stimulation that includes monitoring responses of the nerve or artery/nerve plexus; and
a controller configured to modify the first set of stimulation parameters based on the responses of the nerve or artery/nerve plexus to create a second set of stimulation parameters, wherein the controller is configured to modify the first set of stimulation parameters based on a titration schedule;
wherein the neurostimulator is further configured to deliver the stimulation based on the second set of the stimulation parameters, wherein the neurostimulator, the one or more sensors, and the controller are provided within a distributed environment, and wherein at least the neurostimulator and the controller are in communication via a wireless communication network.