US 12,070,567 B2
Microneedle particles, compositions, and methods of treatment and delivering a substance of interest
Andrew Tadros, Atlanta, GA (US); and Mark R. Prausnitz, Atlanta, GA (US)
Assigned to Georgia Tech Research Corporation, Atlanta, GA (US)
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
Filed on Apr. 4, 2022, as Appl. No. 17/712,755.
Application 17/712,755 is a continuation of application No. 16/079,579, granted, now 11,291,816, previously published as PCT/US2017/020160, filed on Mar. 1, 2017.
Claims priority of provisional application 62/301,780, filed on Mar. 1, 2016.
Prior Publication US 2022/0226626 A1, Jul. 21, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 37/00 (2006.01); A61K 8/02 (2006.01); A61K 9/00 (2006.01); A61K 31/352 (2006.01); A61Q 19/00 (2006.01)
CPC A61M 37/0015 (2013.01) [A61K 8/0204 (2013.01); A61K 8/0245 (2013.01); A61K 9/0021 (2013.01); A61K 31/352 (2013.01); A61Q 19/00 (2013.01); A61K 2800/87 (2013.01); A61K 2800/91 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0046 (2013.01); A61M 2037/0053 (2013.01); A61M 2037/0061 (2013.01)] 24 Claims
 
1. A composition comprising:
a plurality of microneedle particles; and
a liquid medium in which the plurality of microneedle particles is dispersed;
wherein the composition is adapted for application to a biological tissue surface; and
wherein each of the microneedle particles comprises a core structure, and one or more microneedles extending from the core structure, the one or more microneedles being structured to penetrate the biological tissue surface, and wherein at least one of (i) the core structure, (ii) the one or more microneedles, and (iii) a spatial relationship between/among two or more of the microneedles is configured to prevent the entire microneedle particle from penetrating the biological tissue surface.