US 12,070,537 B2
Membrane and device for treating restless leg syndrome
Angelito A. Bernardo, River Forest, IL (US); Angela Sofia Rivera Florez, Port St. Lucie, FL (US); Lars-Goran Nilsson, Hoor (SE); Rafael Mauricio Sanabria Arenas, Bogota (CO); and Alfonso Bunch Barrera, Bogota (CO)
Assigned to GAMBRO LUNDIA AB, Lund (SE)
Filed by GAMBRO LUNDIA AB, Lund (SE)
Filed on Feb. 10, 2022, as Appl. No. 17/668,480.
Application 17/668,480 is a continuation of application No. 16/163,123, filed on Oct. 17, 2018, granted, now 11,278,651.
Prior Publication US 2022/0193315 A1, Jun. 23, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 1/16 (2006.01); A61K 31/197 (2006.01); A61K 31/381 (2006.01); A61K 31/404 (2006.01); A61P 25/00 (2006.01); B01D 61/24 (2006.01); B01D 63/02 (2006.01); B01D 69/02 (2006.01); B01D 69/08 (2006.01); B01D 71/68 (2006.01)
CPC A61M 1/16 (2013.01) [A61K 31/197 (2013.01); A61K 31/381 (2013.01); A61K 31/404 (2013.01); A61P 25/00 (2018.01); B01D 61/243 (2013.01); B01D 63/02 (2013.01); B01D 69/02 (2013.01); B01D 69/084 (2013.01); B01D 71/68 (2013.01); B01D 2325/04 (2013.01); B01D 2325/20 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of treating restless leg syndrome (RLS) in a patient, said method comprising the steps of withdrawing and bypassing the blood of the patient in a continuous flow into contact with one face of a membrane, simultaneously passing dialysate solution in a continuous flow on the opposite face of the membrane, and returning the blood to the patient,
wherein the membrane has a MWRO of between about 9.0 kDa and about 12.0 kDa and a MWCO of between about 55 kDa and about 110 kDa as determined by dextran sieving before blood contact of the membrane, and
wherein the membrane comprises at least one polymer selected from the group of polymers consisting of polysulfone, polyethersulfone and polyarylethersulfone, and further comprising polyvinylpyrrolidone,
wherein treatment with the membrane reduces one or more RLS symptoms in the patient.